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KMID : 0359920070260020174
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Korean Journal of Nephrology
2007 Volume.26 No. 2 p.174 ~ p.181
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The Impact of Serum Uric Acid Level on the Progression of IgA Nephropathy
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Chin Ho-Jun
Na Ki-Young
Cheong Hae-Il
Kim Yon-Su
Kim Suhng-Gwon
Chae Dong-Wan
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Abstract
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Purpose: Many evidences about hyperuricemia as a risk factor to hypertension and renal progression in kidney diseases have been reported. We have analyzed the impact of uric acid on renal progression of IgA nephropathy while getting rid of possible confounding variables and revealed the possible pathophysiology of uric acid in terms of hypertension or renal vasculopathy provoked by uric acid.
Methods: We selected 172 patients with IgA nephropathy diagnosed by renal biopsy at Seoul National University Hospital. We adapted the criteria of renal progression as the final value of serum creatinine increased more then twice compared to the value at renal biopsy.
Results: Serum uric acid was correlated with the severity of interstitial fibrosis and tubular atrophy and the presence of artherosclerosis.
The incidence of hypertension during follow-up period was not different between low uric acid group and high uric acid group.
The high uric acid level was an independent risk factor to renal progression in IgA nephropathy with multivariate analysis regardless of the presence of hypertension or artherosclerosis of renal pathologic finding. The high uric acid level was also a risk factor to renal progression in patients with estimated GFR more than 60mL/min/1.73m2.
Conclusion: Serum uric acid was related to the presence of artherosclerosis and the renal progression of IgA nephropathy.
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KEYWORD
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Uric acid, Hypertension, IgA nephropathy
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